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The English Premier League makes a return after the International break and it promises to provide some mouth-watering clashes this weekend.

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The biggest game of the weekend is arguably the 221st Merseyside Derby. Both Everton and Liverpool have made strong starts this season and it may well prove to be a tight contest at Goodison Park.

Second-placed Liverpool will go into the game knowing that three points will see Brendan Rodgers’ side leapfrog Arsenal into first – for a few hours at least.

Meanwhile, Everton are currently unbeaten at home – having lost just one league game all season – and a win for the Toffees would see them go level on points with their close neighbours.

This season’s surprise package Southampton travel to the Emirates, in what should be an entertaining “First v Third” clash with table-toppers Arsenal.

Like Liverpool, Southampton could feasibly find themselves in pole position by Monday morning, if they can prevail over Arsene Wenger’s men and Everton at least manage a draw.

However, Arsenal will be desperate to record a victory over the Saints – after their disappointing defeat against Manchester United a fortnight ago.

Manchester City-Tottenham also promises to be a must-watch game – as both are sure to go all-out to try and win their encounter and claw themselves back into the European qualification spots.

And while a rejuvinated Sunderland are unlikely to escape the relegation places just yet, Gus Poyet’s men can at least go level on points with 17th-placed Stoke City, with a win at the Britannia Stadium.

Other notable fixtures see Norwich manager Chris Hughton return to St James’ Park – to face off against former club Newcastle – West Brom and Aston Villa contesting the Black Country Derby and David Moyes’ Man Utd side going to Cardiff, looking to build on their 1-0 win over Arsenal last time out.

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